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Mitochondrial Signaling • Metabolic Flexibility • Endurance Support
Available strength: 40mg

MOTS-c

MOTS-c is a mitochondria-derived peptide studied for improving metabolic efficiency, glucose handling, and cellular energy utilization.

$205.90

🗹Supports mitochondrial efficiency & energy utilization

🗹Enhances metabolic flexibility

🗹Improves glucose handling pathways

🗹Popular in longevity & endurance protocols

🗹Frequently stacked with NAD+ and SS-31

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description
MOTS-c is part of a class of mitochondria-derived peptides (MDPs) that act as signaling molecules between mitochondria and the nucleus. These peptides help regulate how cells adapt to metabolic stress and energy demand. Research has explored MOTS-c for its influence on:
  • Insulin sensitivity
  • Glucose utilization
  • Fat metabolism
  • Cellular energy efficiency
  • Adaptive stress responses
Because mitochondrial health underpins endurance, longevity, and metabolic performance, MOTS-c is commonly included in protocols focused on energy resilience and healthy aging.

Supported by mitochondrial biology and metabolic research.

Mitochondrial Energy Support

Helps optimize how cells convert nutrients into usable energy.

Improved Metabolic Flexibility

Supports efficient switching between glucose and fat as fuel sources.

Insulin Sensitivity Pathways

Often explored in protocols addressing metabolic efficiency.

Endurance & Physical Capacity

Popular in training and performance-oriented research stacks.

Longevity Protocol Foundation

Commonly paired with NAD+ for cellular repair support.

Body Composition Support

Metabolic optimization may indirectly support recomposition goals.

MOTS-c is supplied as a lyophilized peptide powder. Typical handling guidance: Reconstitute with bacteriostatic water Used cyclically in many protocols Follow practitioner or research guidance for timing and duration

MOTS-c (lyophilized peptide)

No fillers, additives, or preservatives

All batches tested for identity, purity, potency, endotoxins, and sterility.

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Pure Quality

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Quality Tested

Advanced Formulas

Trusted by thousands across the world

98% of reviewers would recommend this product to a friend. Simply Nootropics brings premium nootropics to Europe. Read real stories from our customers who’ve experienced the transformative power of our nootropics and longevity supplements.

Get into the flow state

With our powerful and evidence-based, daily dose of nootropics.

Feel Energised All Day

Boost your daily endurance and vitality with a clinically-formulated nootropic blend that powers up your energy levels, keeping you active and alert.

Feel Energised All Day

Boost your daily endurance and vitality with a clinically-formulated nootropic blend that powers up your energy levels, keeping you active and alert.

Boost your daily endurance and vitality with a clinically-formulated nootropic blend that powers up your energy levels, keeping you active and alert.

Boost your daily endurance and vitality with a clinically-formulated nootropic blend that powers up your energy levels, keeping you active and alert.

Feel Energised All Day

Boost your daily endurance and vitality with a clinically-formulated nootropic blend that powers up your energy levels, keeping you active and alert.

Feel Energised All Day

Boost your daily endurance and vitality with a clinically-formulated nootropic blend that powers up your energy levels, keeping you active and alert.

Studies show that nootropics can improve cognitive functions by up to 20%, including memory recall, focus, and mental clarity.

A holistic way to be at your best every day

Ashwagandha

Daily active: 250mg Adaptogenic, Stress-reducing, Neuroprotective
Ashwagandha, traditionally known as Indian Ginseng, thrives in India's arid regions. Celebrated in Ayurvedic medicine for over 3,000 years, it's acclaimed for reducing stress and anxiety. This adaptogenic herb bolsters cognitive function, enhancing concentration, mental stamina, and mood balance, making it an invaluable ally for mental clarity and stress resilience.

Ashwagandha

Daily active: 250mg Adaptogenic, Stress-reducing, Neuroprotective
Ashwagandha, traditionally known as Indian Ginseng, thrives in India's arid regions. Celebrated in Ayurvedic medicine for over 3,000 years, it's acclaimed for reducing stress and anxiety. This adaptogenic herb bolsters cognitive function, enhancing concentration, mental stamina, and mood balance, making it an invaluable ally for mental clarity and stress resilience.

Ashwagandha

Daily active: 250mg Adaptogenic, Stress-reducing, Neuroprotective
Ashwagandha, traditionally known as Indian Ginseng, thrives in India's arid regions. Celebrated in Ayurvedic medicine for over 3,000 years, it's acclaimed for reducing stress and anxiety. This adaptogenic herb bolsters cognitive function, enhancing concentration, mental stamina, and mood balance, making it an invaluable ally for mental clarity and stress resilience.

Ashwagandha

Daily active: 250mg Adaptogenic, Stress-reducing, Neuroprotective
Ashwagandha, traditionally known as Indian Ginseng, thrives in India's arid regions. Celebrated in Ayurvedic medicine for over 3,000 years, it's acclaimed for reducing stress and anxiety. This adaptogenic herb bolsters cognitive function, enhancing concentration, mental stamina, and mood balance, making it an invaluable ally for mental clarity and stress resilience.

Ashwagandha

Daily active: 250mg Adaptogenic, Stress-reducing, Neuroprotective
Ashwagandha, traditionally known as Indian Ginseng, thrives in India's arid regions. Celebrated in Ayurvedic medicine for over 3,000 years, it's acclaimed for reducing stress and anxiety. This adaptogenic herb bolsters cognitive function, enhancing concentration, mental stamina, and mood balance, making it an invaluable ally for mental clarity and stress resilience.

Ashwagandha

Daily active: 250mg Adaptogenic, Stress-reducing, Neuroprotective
Ashwagandha, traditionally known as Indian Ginseng, thrives in India's arid regions. Celebrated in Ayurvedic medicine for over 3,000 years, it's acclaimed for reducing stress and anxiety. This adaptogenic herb bolsters cognitive function, enhancing concentration, mental stamina, and mood balance, making it an invaluable ally for mental clarity and stress resilience.

Dr. Brian P. Ramos

Backed by science

Meet Dr. Brian P. Ramos, our in-house Yale neuroscientist with a PhD in Neurobiology.
Dr. Ramos has devoted his life to uncovering how we can live healthier, happier lives, with the right nutrients.
Specialising in cognitive support and longevity, his focus has always been on delivering real, science-backed results for enhanced well-being.

The Amino Arcade Standard

We don’t just follow trends we engineer them.Our compounds are sourced, synthesized, and verified through world-class manufacturing partners.Every vial and capsule reflects our mission: science that performs.Reliable. Tested. Retro-powered science.

The Amino Arcade Standard

We don’t just follow trends we engineer them.Our compounds are sourced, synthesized, and verified through world-class manufacturing partners.Every vial and capsule reflects our mission: science that performs.Reliable. Tested. Retro-powered science.

The Amino Arcade Standard

We don’t just follow trends we engineer them.Our compounds are sourced, synthesized, and verified through world-class manufacturing partners.Every vial and capsule reflects our mission: science that performs.Reliable. Tested. Retro-powered science.

The Amino Arcade Standard

We don’t just follow trends we engineer them.Our compounds are sourced, synthesized, and verified through world-class manufacturing partners.Every vial and capsule reflects our mission: science that performs.Reliable. Tested. Retro-powered science.

LEADING COMPETITORS - CHEMISTS 2025

CASH RECEIPT

ASHWAGANDHA
BACOPA MONNIERI
CDP CHOLINE
L-THEANINE
LIONS MANE MASHROOM
NZ PINE BARK EXTRACT
PANAX GINSENG
RHODIOLA ROSEA
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€16

Over  €111.00

Frequently asked questions

Our local team are here to help.

Chat with our customer support team, Monday-Friday.

Or contact us via email at:

support@aminoarcade.com

Is MOTS-c more “energy” or “fat loss”?
It’s primarily metabolic—energy efficiency and glucose handling that can support body composition.
Can it be stacked with NAD+?
Yes—one supports mitochondrial signaling, the other supports cellular coenzyme levels.
Is it daily or weekly?
Protocols vary; many use short cycles or multi-week schedules.

After the age of 30, your brain function can start to decline by about 1% per year. Upgrade your brain with our nootropics and stay sharp as a tack.

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We’ve got the data

We read the clinical studies so you don’t have to. Here’s what the science says.

Plas Reconstr Surg, 2021

BBRC, 2024

Trends Mol Med, 2017

Trends Mol Med, 2017

Curr Dev Nutr, 2022

GeroScience, 2023

Cell Metab, 2019

PLoS One, 2012

1. A review of clinical and preclinical studies that demonstrate the role of NAD+ in healthy aging.

2. This review study presents clinical evidence of NAD+ supplementation via NAD+ precursors in disease pathology and prevention.

3. This review study of preclinical and clinical trials examines how NAD+ addresses the molecular hallmarks of aging including healthy metabolism, DNA repair, cellular energy, cognitive function, and gene expression.

4. A clinical study of 30 Parkinson’s patients treated with NAD+ via oral NAD+ precursors showing improvement to overall brain functioning

5. This review study analyzes 7 peer-reviewed preclinical studies, concluding that the available evidence shows that NAD+ precursors may improve immune function.

6. This clinical trial examined 80 middle-aged adults taking 300-900mg of an NAD+ precursor, with increased energy measured by improved walking distance and enhanced quality of life.

7. A review of available in vivo evidence of the essential functions of NAD+ in human cells.

8. This clinical trial examines patients aged 15-77 and newborn babies aged 0-1 to analyze the variable levels of NAD+ present at different stages in the aging process.

Disclaimer:

Research and educational use only. Not for human consumption.